As of the 2005-06 school year, the school had an enrollment of 2,086 students and 93 classroom teachers (on a FTE basis) for a student-teacher ratio of 22.4.

During the 1988-89 school year, Cape Coral High School was recognized with the Blue Ribbon School Award of Excellence by the United States Department of Education, the highest award an American school can receive.

In 1996, Cape Coral High School's newspaper The Shell won the NSPA's high school newspaper competition in Orlando, FL. It went on to rank 8th nationally. In 1997, The Shell repeated its win for the state of Florida. The paper continues to do well in many competitions, including a First Place award from the American Scholastic Press Association (ASPA) during the 2008-2009 school year.

In the spring of 2006, the school was one of 17 in Florida selected as part of Sports Illustrated’s "model SI Schools steroid and drug prevention initiative" for high school athletes.

In April 2007 the school was awarded accreditation by the International Baccalaureate Organization to offer the IB Diploma Programme, making it the second IB school in Lee County and putting the school on track to graduate its first IB class in 2009.

Cape Coral High offers many diverse classes. Some offered classes included Honors, AP, and IB classes. The school also offers foreign language classes including Spanish and French.

In February 2008 the Model United Nations brought home the "Best Large Delegation" award from BosMUN, a conference in Boston, MA hosted by MIT and Boston University. This conference was attended by schools across the world including those from Canada, China, and Guatemala. Student representatives were the recipients of several "Best", "Outstanding", and "Honorable Mention" awards. This feat was repeated in 2010, where delegations came from 5 different continents, including a delegation from Ghana. Cape High students took home 15 individual awards, and the "Best Large Delegation" award once again.

March 2008 marked the first time that Cape Coral High School has hosted a regional math competition. At the competition, Cape Coral High School placed first among Lee County high schools, and fourth among overall participating high schools.

Cape Coral High School offers a variety of athletic programs for students during the fall, winter and spring. Sports offered include:

In 2010, two of Cape Coral High School's teachers, Mr. Michael Cook and Mr. Robert Snyder, received the Golden Apple Award, given to only five teachers every year. It is a first for a single school to have two Golden Apple Winners in one year because there are numerous schools in the Lee County district area.